Det anbefales zoledronsyre 4 mg i.v. hver 4. uke i 2 år. Hvis pasienten oppnår VGPR kan behandling avsluttes etter minst 1 års behandling. Deretter eventuelt re-oppstart ved skjelettprogresjon.
Denosumab kan vurderes ved kontraindikasjon for zoledronsyre.
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