7. Adjuvant og neo-adjuvant systemisk behandling
7. 1. Adjuvant behandling
7. 2. Adjuvant hormonbehandling
7. 3. Adjuvant ikke-hormonell behandling
7. 4. Oversikt over anbefalt adjuvant behandling
7. 5. Alternative adjuvante behandlingsregimer
7. 6. Spesielle instruksjoner ved ikke-hormonell behandling
7. 7. Bivirkninger av kjemoterapi – overvåking og håndtering av disse
7. 8. Spesielle forhold ved adjuvant behandling av HER2 positive pasienter hvor det er indikasjon for anti-HER2 behandling
7. 9. Neoadjuvant behandling
Aapro, M. S., Bohlius, J., Cameron, D. A., Dal Lago, L., Donnelly, J. P., Kearney, N., Lyman, G. H., Pettengell, R., ... Treatment of, C. (2011). 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours. European journal of cancer, 47(1), 8-32.
Albain, K. S., Barlow, W. E., Shak, S., Hortobagyi, G. N., Livingston, R. B., Yeh, I. T., Ravdin, P., Bugarini, R., ... Hayes, D. F. (2010). Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. The Lancet. Oncology, 11(1), 55-65.
Allred, D. C., Anderson, S. J., Paik, S., Wickerham, D. L., Nagtegaal, I. D., Swain, S. M., Mamounas, E. P., Julian, T. B., ... Wolmark, N. (2012). Adjuvant tamoxifen reduces subsequent breast cancer in women with estrogen receptor-positive ductal carcinoma in situ: a study based on NSABP protocol B-24. Journal of clinical oncology, 30(12), 1268-73.
Amir, E., Seruga, B., Niraula, S., Carlsson, L., & Ocana, A. (2011). Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: a systematic review and meta-analysis. Journal of the National Cancer Institute, 103(17), 1299-1309.
An, X., Lei, X., Huang, R., Luo, R., Li, H., Xu, F., Yuan, Z., Wang, S., ... Shi, Y. (2020). Adjuvant chemotherapy for small, lymph node-negative, triple-negative breast cancer: A single-center study and a meta-analysis of the published literature. Cancer, 126 Suppl 16, 3837-3846.
Andre, F., Broglio, K., Roche, H., Martin, M., Mackey, J. R., Penault-Llorca, F., Hortobagyi, G. N., & Pusztai, L. (2008). Estrogen receptor expression and efficacy of docetaxel-containing adjuvant chemotherapy in patients with node-positive breast cancer: results from a pooled analysis. Journal of clinical oncology, 26(16), 2636-2643.
Andre, F., Ismaila, N., Allison, K. H., Barlow, W. E., Collyar, D. E., Damodaran, S., Henry, N. L., Jhaveri, K., ... Stearns, V. (2022). Biomarkers for Adjuvant Endocrine and Chemotherapy in Early-Stage Breast Cancer: ASCO Guideline Update. Journal of clinical oncology, 40(16), 1816-1837.
Andre, F., Ismaila, N., Henry, N. L., Somerfield, M. R., Bast, R. C., Barlow, W., Collyar, D. E., Hammond, M. E., ... Stearns, V. (2019). Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update-Integration of Results From TAILORx. Journal of clinical oncology, 37(22), 1956-1964.
Asleh, K., Lluch, A., Goytain, A., Barrios, C., Wang, X. Q., Torrecillas, L., Gao, D., Ruiz-Borrego, M., ... Martin, M. (2023). Triple-Negative PAM50 Non-Basal Breast Cancer Subtype Predicts Benefit from Extended Adjuvant Capecitabine. Clinical cancer research, 29(2), 389-400.
Baak, J. P., van Diest, P. J., Janssen, E. A., Gudlaugsson, E., Voorhorst, F. J., van der Wall, E., & Vermorken, J. B. (2008). Proliferation accurately identifies the high-risk patients among small, low-grade, lymph node-negative invasive breast cancers. Annals of oncology, 19(4), 649-54.
Baak, J. P., van Diest, P. J., Voorhorst, F. J., van der Wall, E., Beex, L. V., Vermorken, J. B., Janssen, E. A., & Gudlaugsson, E. (2007). The prognostic value of proliferation in lymph-node-negative breast cancer patients is age dependent. European journal of cancer, 43(3), 527-35.
Baek, S. Y., Noh, W. C., Ahn, S. H., Kim, H. A., Ryu, J. M., Kim, S. I., Lee, E. G., Im, S. A., ... Kim, H. J. (2023). Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor-Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial. Journal of clinical oncology, 41(31), 4864-4871.
Bailey, A. G., Brown, J. N., & Hammond, J. M. (2021). Cryotherapy for the prevention of chemotherapy-induced peripheral neuropathy: A systematic review. Journal of oncology pharmacy practice, 27(1), 156-164.
Banke, A., Fosbøl, E. L., Møller, J. E., Gislason, G. H., Andersen, M., Bernsdorf, M., Jensen, M. B., Schou, M., & Ejlertsen, B. (2018). Long-term effect of epirubicin on incidence of heart failure in women with breast cancer: insight from a randomized clinical trial. European journal of heart failure, 20(10), 1447-1453.
Berry, D. A., Cirrincione, C., Henderson, I. C., Citron, M. L., Budman, D. R., Goldstein, L. J., Martino, S., Perez, E. A., ... Winer, E. P. (2006). Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA, 295(14), 1658-1667.
Biganzoli, L., Battisti, N. M. L., Wildiers, H., McCartney, A., Colloca, G., Kunkler, I. H., Cardoso, M. J., Cheung, K. L., ... Brain, E. G. C. (2021). Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG). The Lancet. Oncology, 22(7), e327-e340.
Biganzoli, L., Wildiers, H., Oakman, C., Marotti, L., Loibl, S., Kunkler, I., Reed, M., Ciatto, S., ... Audisio, R. (2012). Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). The Lancet. Oncology, 13(4), e148-e160.
Bliss, J. M., Kilburn, L. S., Coleman, R. E., Forbes, J. F., Coates, A. S., Jones, S. E., Jassem, J., Delozier, T., ... Coombes, R. C. (2012). Disease-related outcomes with long-term follow-up: an updated analysis of the intergroup exemestane study. Journal of clinical oncology, 30(7), 709-717.
Blohmer, J. U., Link, T., Reinisch, M., Just, M., Untch, M., Stötzer, O., Fasching, P. A., Schneeweiss, A., ... Loibl, S. (2022). Effect of Denosumab Added to 2 Different nab-Paclitaxel Regimens as Neoadjuvant Therapy in Patients With Primary Breast Cancer: The GeparX 2 × 2 Randomized Clinical Trial. JAMA oncology, 8(7), 1010-1018.
Blok, E. J., Kroep, J. R., Meershoek-Klein Kranenbarg, E., Duijm-de Carpentier, M., Putter, H., van den Bosch, J., Maartense, E., van Leeuwen-Stok, A. E., ... van de Velde, C. J. H. (2018). Optimal Duration of Extended Adjuvant Endocrine Therapy for Early Breast Cancer; Results of the IDEAL Trial (BOOG 2006-05). Journal of the National Cancer Institute, 110(1)
Blum, J. L., Flynn, P. J., Yothers, G., Asmar, L., Geyer, C. E. ,. J., Jacobs, S. A., Robert, N. J., Hopkins, J. O., ... Wolmark, N. (2017). Anthracyclines in Early Breast Cancer: The ABC Trials-USOR 06-090, NSABP B-46-I/USOR 07132, and NSABP B-49 (NRG Oncology). Journal of clinical oncology, 35(23), 2647-2655.
Bolzacchini, E., Pomero, F., Fazio, M., Civitelli, C., Fabro, G., Pellegrino, D., Giordano, M., & Squizzato, A. (2021). Risk of venous and arterial thromboembolic events in women with advanced breast cancer treated with CDK 4/6 inhibitors: A systematic review and meta-analysis. Thrombosis research, 208, 190-197.
Bonneterre, J., Roche, H., Kerbrat, P., Bremond, A., Fumoleau, P., Namer, M., Goudier, M. J., Schraub, S., ... Chapelle-Marcillac, I. (2005). Epirubicin increases long-term survival in adjuvant chemotherapy of patients with poor-prognosis, node-positive, early breast cancer: 10-year follow-up results of the French Adjuvant Study Group 05 randomized trial. Journal of clinical oncology, 23(12), 2686-2693.
Bouchardy, C., Rapiti, E., Blagojevic, S., Vlastos, A. T., & Vlastos, G. (2007). Older female cancer patients: importance, causes, and consequences of undertreatment. Journal of clinical oncology, 25(14), 1858-1869.
Broglio, K. R., Quintana, M., Foster, M., Olinger, M., McGlothlin, A., Berry, S. M., Boileau, J. F., Brezden-Masley, C., ... Berry, D. A. (2016). Association of Pathologic Complete Response to Neoadjuvant Therapy in HER2-Positive Breast Cancer With Long-Term Outcomes: A Meta-Analysis. JAMA oncology, 2(6), 751-60.
Brufsky, A. M., Harker, W. G., Beck, J. T., Bosserman, L., Vogel, C., Seidler, C., Jin, L., Warsi, G., ... Perez, E. A. (2012). Final 5-year results of Z-FAST trial: adjuvant zoledronic acid maintains bone mass in postmenopausal breast cancer patients receiving letrozole. Cancer, 118(5), 1192-1201.
Burstein, H. J., Curigliano, G., Gnant, M., Loibl, S., Regan, M. M., Loi, S., Denkert, C., Poortmans, P., ... Weber, W. P. (2025). Tailoring treatment to cancer risk and patient preference: the 2025 St Gallen International Breast Cancer Consensus Statement on individualizing therapy for patients with early breast cancer. Annals of oncology, 36(12), 1433-1446.
Burstein, H. J., Curigliano, G., Loibl, S., Dubsky, P., Gnant, M., Poortmans, P., Colleoni, M., Denkert, C., ... Thurlimann, B. (2019). Estimating the Benefits of Therapy for Early Stage Breast Cancer The St Gallen International Consensus Guidelines for the Primary Therapy of Early Breast Cancer 2019. Annals of oncology, 30(10), 1541-1557.
Burstein, H. J., Curigliano, G., Thürlimann, B., Weber, W. P., Poortmans, P., Regan, M. M., Senn, H. J., Winer, E. P., & Gnant, M. (2021). Customizing local and systemic therapies for women with early breast cancer: the St. Gallen International Consensus Guidelines for treatment of early breast cancer 2021. Annals of oncology, 32(10), 1216-1235.
Burstein, H. J., Somerfield, M. R., Barton, D. L., Dorris, A., Fallowfield, L. J., Jain, D., Johnston, S. R. D., Korde, L. A., ... Rugo, H. S. (2021). Endocrine Treatment and Targeted Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer: ASCO Guideline Update. Journal of clinical oncology, 39(35), 3959-3977.
Byrski, T., Huzarski, T., Dent, R., Marczyk, E., Jasiowka, M., Gronwald, J., Jakubowicz, J., Cybulski, C., ... Narod, S. A. (2014). Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast cancer research and treatment, 147(2), 401-5.
Cameron, D., Piccart-Gebhart, M. J., Gelber, R. D., Procter, M., Goldhirsch, A., de Azambuja, E., Castro, G. ,. J., Untch, M., ... Jackisch, C. (2017). 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial. Lancet, 389(10075), 1195-1205.
Cardoso, F., van't Veer, L. J., Bogaerts, J., Slaets, L., Viale, G., Delaloge, S., Pierga, J. Y., Brain, E., ... Piccart, M. (2016). 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer. New England Journal of Medicine, 375(8), 717-29.
Caudle, K. E., Sangkuhl, K., Whirl-Carrillo, M., Swen, J. J., Haidar, C. E., Klein, T. E., Gammal, R. S., Relling, M. V., ... Gaedigk, A. (2020). Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group. Clinical and translational science, 13(1), 116-124.
Cheang, M. C., Martin, M., Nielsen, T. O., Prat, A., Voduc, D., Rodriguez-Lescure, A., Ruiz, A., Chia, S., ... Carey, L. A. (2015). Defining breast cancer intrinsic subtypes by quantitative receptor expression. The oncologist, 20(5), 474-82.
Chen, X. C., Jiao, D. C., Qiao, J. H., Wang, C. Z., Sun, X. F., Lu, Z. D., Li, L. F., Zhang, C. J., ... Liu, Z. Z. (2025). De-escalated neoadjuvant weekly nab-paclitaxel with trastuzumab and pertuzumab versus docetaxel, carboplatin, trastuzumab, and pertuzumab in patients with HER2-positive early breast cancer (HELEN-006): a multicentre, randomised, phase 3 trial. The Lancet. Oncology, 26(1), 27-36.
Choong, G. M., Hoskin, T. L., Boughey, J. C., Ingle, J. N., & Goetz, M. P. (2025). Endocrine Therapy Omission in Estrogen Receptor-Low (1%-10%) Early-Stage Breast Cancer. Journal of clinical oncology, 43(16), 1875-1885.
Coates, A. S., Keshaviah, A., Thurlimann, B., Mouridsen, H., Mauriac, L., Forbes, J. F., Paridaens, R., Castiglione-Gertsch, M., ... Goldhirsch, A. (2007). Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98. Journal of clinical oncology, 25(5), 486-492.
Coates, A. S., Winer, E. P., Goldhirsch, A., Gelber, R. D., Gnant, M., Piccart-Gebhart, M., Thurlimann, B., & Senn, H. J. (2015). Tailoring therapies-improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015. Annals of oncology, 26(8), 1533-46.
Coleman, R., Finkelstein, D. M., Barrios, C., Martin, M., Iwata, H., Hegg, R., Glaspy, J., Periañez, A. M., ... Chan, A. (2020). Adjuvant denosumab in early breast cancer (D-CARE): an international, multicentre, randomised, controlled, phase 3 trial. The Lancet. Oncology, 21(1), 60-72.
Coleman, R. E., Marshall, H., Cameron, D., Dodwell, D., Burkinshaw, R., Keane, M., Gil, M., Houston, S. J., ... Bell, R. (2011). Breast-cancer adjuvant therapy with zoledronic acid. New England Journal of Medicine, 365(15), 1396-1405.
Conte, P., Bisagni, G., Piacentini, F., Sarti, S., Minichillo, S., Anselmi, E., Aieta, M., Gebbia, V., ... Guarneri, V. (2023). Nine-Week Versus One-Year Trastuzumab for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: 10-Year Update of the ShortHER Phase III Randomized Trial. Journal of clinical oncology, 41(32), 4976-4981.
Coombes, R. C., Kilburn, L. S., Snowdon, C. F., Paridaens, R., Coleman, R. E., Jones, S. E., Jassem, J., Van de Velde, C. J., ... Bliss, J. M. (2007). Survival and safety of exemestane versus tamoxifen after 2-3 years' tamoxifen treatment (Intergroup Exemestane Study): a randomised controlled trial. Lancet, 369(9561), 559-570.
Cortazar, P., Zhang, L., Untch, M., Mehta, K., Costantino, J. P., Wolmark, N., Bonnefoi, H., Cameron, D., ... von Minckwitz, G. (2014). Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet, 384(9938), 164-72.
Crivellari, D., Aapro, M., Leonard, R., von Minckwitz, G., Brain, E., Goldhirsch, A., Veronesi, A., & Muss, H. (2007). Breast cancer in the elderly. Journal of clinical oncology, 25(14), 1882-1890.
Crown, J. P., Stroyakovskiy, D., Yardley, D., Huang, C. S., Fasching, P. A., Bardia, A., Chia, S., Im, S. A., ... Loi, S. (2025). LBA14 Adjuvant ribociclib (RIB) plus nonsteroidal aromatase inhibitor (NSAI) in patients (pts) with HR+/HER2 - early breast cancer (EBC): NATALEE 5-year outcomes. Annals of Oncology, 36(Suppl 2), S1559.
Curigliano, G., Burstein, H. J., E, P. W., Gnant, M., Dubsky, P., Loibl, S., Colleoni, M., Regan, M. M., ... Xu, B. (2017). De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017. Annals of oncology, 28(8), 1700-1712.
Curigliano, G., Burstein, H. J., Gnant, M., Loibl, S., Cameron, D., Regan, M. M., Denkert, C., Poortmans, P., ... St Gallen Consensus Conference Panelists (2023). Understanding breast cancer complexity to improve patient outcomes: The St Gallen International Consensus Conference for the Primary Therapy of Individuals with Early Breast Cancer 2023. Annals of oncology, 34(11), 970-986.
Cuzick, J., Sestak, I., Baum, M., Buzdar, A., Howell, A., Dowsett, M., & Forbes, J. F. (2010). Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial. The Lancet. Oncology, 11(12), 1135-1141.
Cuzick, J., Sestak, I., Forbes, J. F., Dowsett, M., Knox, J., Cawthorn, S., Saunders, C., Roche, N., ... Howell, A. (2014). Anastrozole for prevention of breast cancer in high-risk postmenopausal women (IBIS-II): an international, double-blind, randomised placebo-controlled trial. Lancet, 383(9922), 1041-8.
Davies, C., Godwin, J., Gray, R., Clarke, M., Cutter, D., Darby, S., McGale, P., Pan, H. C., ... Peto, R. (2011). BØR BYTTES! Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet, 378(9793), 771-784.
Davies, C., Pan, H., Godwin, J., Gray, R., Arriagada, R., Raina, V., Abraham, M., Medeiros Alencar, V. H., ... Peto, R. (2013). Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet, 381(9869), 805-816.
de Boer, R., Bundred, N., Eidtmann, H., Neven, P., von Minckwitz, G., Martin, N., ... Modi, A. (2011). Long-Term Survival Outcomes among Postmenopausal Women with Hormone Receptor-Positive Early Breast Cancer Receiving Adjuvant Letrozole and Zoledronic Acid: 5-Year Follow-Up of ZO-FAST. San Antonio: Cancer Therapy & Research Center at UT Health Science Center. Hentet fra http://cancerres.aacrjournals.org/content/71/24_Supplement/S1-3
de Gregorio, A., Janni, W., Friedl, T. W. P., Nitz, U., Rack, B., Schneeweiss, A., Kates, R., Fehm, T., ... Harbeck, N. (2022). The impact of anthracyclines in intermediate and high-risk HER2-negative early breast cancer-a pooled analysis of the randomised clinical trials PlanB and SUCCESS C. British Journal of Cancer, 126(12), 1715-1724.
Del Mastro, L., Bruzzi, P., Nicolo, G., Cavazzini, G., Contu, A., D'Amico, M., Lavarello, A., Testore, F., ... Venturini, M. (2005). HER2 expression and efficacy of dose-dense anthracycline-containing adjuvant chemotherapy in breast cancer patients. British Journal of Cancer, 93(1), 7-14.
Del Mastro, L., De Placido, S., Bruzzi, P., De Laurentiis, M., Boni, C., Cavazzini, G., Durando, A., Turletti, A., ... Cognetti, F. (2015). Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 x 2 factorial, randomised phase 3 trial. Lancet, 385(9980), 1863-72.
Denduluri, N., Chavez-MacGregor, M., Telli, M. L., Eisen, A., Graff, S. L., Hassett, M. J., Holloway, J. N., Hurria, A., ... Giordano, S. H. (2018). Selection of Optimal Adjuvant Chemotherapy and Targeted Therapy for Early Breast Cancer: ASCO Clinical Practice Guideline Focused Update. Journal of clinical oncology, 36(23), 2433-2443.
Dieci, M. V., Griguolo, G., Bottosso, M., Tsvetkova, V., Giorgi, C. A., Vernaci, G., Michieletto, S., Angelini, S., ... Guarneri, V. (2021). Impact of estrogen receptor levels on outcome in non-metastatic triple negative breast cancer patients treated with neoadjuvant/adjuvant chemotherapy. NPJ breast cancer, 7(1), 101.
Dowsett, M., Forbes, J. F., Bradley, R., Ingle, J., Aihara, T., Bliss, J., Boccardo, F., Coates, A., ... Gray, R. (2015). Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. Lancet, 386(10001), 1341-52.
Dowsett, M., Sestak, I., Lopez-Knowles, E., Sidhu, K., Dunbier, A. K., Cowens, J. W., Ferree, S., Storhoff, J., ... Cuzick, J. (2013). Comparison of PAM50 risk of recurrence score with oncotype DX and IHC4 for predicting risk of distant recurrence after endocrine therapy. Journal of clinical oncology, 31(22), 2783-90.
Dowsett, M., Sestak, I., Regan, M. M., Dodson, A., Viale, G., Thurlimann, B., Colleoni, M., & Cuzick, J. (2018). Integration of Clinical Variables for the Prediction of Late Distant Recurrence in Patients With Estrogen Receptor-Positive Breast Cancer Treated With 5 Years of Endocrine Therapy: CTS5. Journal of clinical oncology, 36(19), 1941-1948.
Earl, H. M., Hiller, L., Vallier, A. L., Loi, S., McAdam, K., Hughes-Davies, L., Harnett, A. N., Ah-See, M. L., ... Dunn, J. A. (2019). 6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial. Lancet, 393(10191), 2599-2612.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2005). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet, 365(9472), 1687-1717.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2019). Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials. Lancet, 393(10179), 1440-1452.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2022). Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials. The Lancet. Oncology, 23(3), 382-392.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG) (2025). Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy. Lancet, 406(10503), 603-614.
Early Breast Cancer Trialists’ Collaborative group (EBCTCG) (2021). Trastuzumab for early-stage, HER2-positive breast cancer: a meta-analysis of 13 864 women in seven randomised trials. The Lancet. Oncology, 22(8), 1139-1150.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) (2023). Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100 000 women from 86 randomised trials. Lancet, 401(10384), 1277-1292.
Eidtmann, H., de Boer, R., Bundred, N., Llombart-Cussac, A., Davidson, N., Neven, P., von Minckwitz, G., Miller, J., ... Coleman, R. (2010). Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study. Annals of oncology, 21(11), 2188-2194.
Eisen, A., Somerfield, M. R., Accordino, M. K., Blanchette, P. S., Clemons, M. J., Dhesy-Thind, S., Dillmon, M. S., D'Oronzo, S., ... Van Poznak, C. H. (2022). Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update. Journal of clinical oncology, 40(7), 787-800.
Ejlertsen, B., Tuxen, M. K., Jakobsen, E. H., Jensen, M. B., Knoop, A. S., Højris, I., Ewertz, M., Balslev, E., ... Mouridsen, H. T. (2017). Adjuvant Cyclophosphamide and Docetaxel With or Without Epirubicin for Early TOP2A-Normal Breast Cancer: DBCG 07-READ, an Open-Label, Phase III, Randomized Trial. Journal of clinical oncology, 35(23), 2639-2646.
Fasching, P. A., Schmatloch, S., Hauke, J., Rey, J., Jackisch, C., Klare, P., Link, T., Hanusch, C., ... Loibl, S. (2023). Abstract GS5-02: Neoadjuvant paclitaxel/olaparib in comparison to paclitaxel/carboplatinum in patients with HER2-negative breast cancer and homologous recombination deficiency – long-term survival of the GeparOLA study. Cancer Research, 83(5 Suppl), GS5-02.
Fasching, P. A., Stroyakovskiy, D., Yardley, D., Huang, C. S., Crown, J. P., Bardia, A., Chia, S., Im, S. A., ... Hurvitz, S. A. (2024). LBA13 Adjuvant ribociclib (RIB) plus nonsteroidal aromatase inhibitor (NSAI) in patients (Pts) with HR+/HER2- early breast cancer (EBC): 4-year outcomes from the NATALEE trial. Annals of Oncology, 35(Suppl 2), S1207.
Ferguson, T., Wilcken, N., Vagg, R., Ghersi, D., & Nowak, A. K. (2007). Taxanes for adjuvant treatment of early breast cancer. Cochrane database of systematic reviews, (4), CD004421.
Filipits, M., Nielsen, T. O., Rudas, M., Greil, R., Stoger, H., Jakesz, R., Bago-Horvath, Z., Dietze, O., ... Gnant, M. (2014). The PAM50 risk-of-recurrence score predicts risk for late distant recurrence after endocrine therapy in postmenopausal women with endocrine-responsive early breast cancer. Clinical cancer research, 20(5), 1298-305.
Forbes, J. F., Cuzick, J., Buzdar, A., Howell, A., Tobias, J. S., & Baum, M. (2008). Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. The Lancet. Oncology, 9(1), 45-53.
Francis, P., Crown, J., Di, L. A., Buyse, M., Balil, A., Andersson, M., Nordenskjold, B., Lang, I., ... Piccart-Gebhart, M. (2008). Adjuvant chemotherapy with sequential or concurrent anthracycline and docetaxel: Breast International Group 02-98 randomized trial. Journal of the National Cancer Institute, 100(2), 121-133.
Francis, P. A., Fleming, G. F., Láng, I., Ciruelos, E. M., Bonnefoi, H. R., Bellet, M., Bernardo, A., Climent, M. A., ... Regan, M. M. (2023). Adjuvant Endocrine Therapy in Premenopausal Breast Cancer: 12-Year Results From SOFT. Journal of clinical oncology, 41(7), 1370-1375.
Francis, P. A., Pagani, O., Fleming, G. F., Walley, B. A., Colleoni, M., Lang, I., Gomez, H. L., Tondini, C., ... Regan, M. M. (2018). Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer. New England Journal of Medicine, 379(2), 122-137.
Francis, P. A., Regan, M. M., Fleming, G. F., Lang, I., Ciruelos, E., Bellet, M., Bonnefoi, H. R., Climent, M. A., ... Gelber, R. D. (2015). Adjuvant ovarian suppression in premenopausal breast cancer. New England Journal of Medicine, 372(5), 436-46.
Friedl, T. W. P., Fehm, T., Müller, V., Lichtenegger, W., Blohmer, J., Lorenz, R., Forstbauer, H., Fink, V., ... Rack, B. (2021). Prognosis of Patients With Early Breast Cancer Receiving 5 Years vs 2 Years of Adjuvant Bisphosphonate Treatment: A Phase 3 Randomized Clinical Trial. JAMA oncology, 7(8), 1149-1157.
Gao, H., Li, W., Wu, Z., Dong, J., Cao, Y., Zhao, Y., Chen, Q., Ma, S., ... Wang, K. (2025). De-escalated neoadjuvant taxane plus trastuzumab and pertuzumab with or without carboplatin in HER2-positive early breast cancer (neoCARHP): A multicentre, open-label, randomised, phase 3 trial. Journal of Clinical Oncology, 43(17 suppl), LBA500.
Geyer, C. E. ,. J., Garber, J. E., Gelber, R. D., Yothers, G., Taboada, M., Ross, L., Rastogi, P., Cui, K., ... Tutt, A. N. J. (2022). Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer. Annals of oncology, 33(12), 1250-1268.
Geyer, C. E., Sikov, W. M., Huober, J., Rugo, H. S., Wolmark, N., O'Shaughnessy, J., Maag, D., Untch, M., ... Loibl, S. (2022). Long-term efficacy and safety of addition of carboplatin with or without veliparib to standard neoadjuvant chemotherapy in triple-negative breast cancer: 4-year follow-up data from BrighTNess, a randomized phase III trial. Annals of oncology, 33(4), 384-394.
Gianni, L., Mansutti, M., Anton, A., Calvo, L., Bisagni, G., Bermejo, B., Semiglazov, V., Thill, M., ... Tusquets, I. (2018). Comparing Neoadjuvant Nab-paclitaxel vs Paclitaxel Both Followed by Anthracycline Regimens in Women With ERBB2/HER2-Negative Breast Cancer-The Evaluating Treatment With Neoadjuvant Abraxane (ETNA) Trial: A Randomized Phase 3 Clinical Trial. JAMA oncology, 4(3), 302-308.
Gianni, L., Pienkowski, T., Im, Y. H., Tseng, L. M., Liu, M. C., Lluch, A., Staroslawska, E., de la Haba-Rodriguez, J., ... Valagussa, P. (2016). 5-year analysis of neoadjuvant pertuzumab and trastuzumab in patients with locally advanced, inflammatory, or early-stage HER2-positive breast cancer (NeoSphere): a multicentre, open-label, phase 2 randomised trial. The Lancet. Oncology, 17(6), 791-800.
Gluz, O., Nitz, U. A., Christgen, M., Kates, R. E., Shak, S., Clemens, M., Kraemer, S., Aktas, B., ... Harbeck, N. (2016). West German Study Group Phase III PlanB Trial: First Prospective Outcome Data for the 21-Gene Recurrence Score Assay and Concordance of Prognostic Markers by Central and Local Pathology Assessment. Journal of clinical oncology, 34(20), 2341-9.
Gnant, M., Dueck, A. C., Frantal, S., Martin, M., Burstein, H. J., Greil, R., Fox, P., Wolff, A. C., ... Mayer, E. L. (2022). Adjuvant Palbociclib for Early Breast Cancer: The PALLAS Trial Results (ABCSG-42/AFT-05/BIG-14-03). Journal of clinical oncology, 40(3), 282-293.
Gnant, M., Fitzal, F., Rinnerthaler, G., Steger, G. G., Greil-Ressler, S., Balic, M., Heck, D., Jakesz, R., ... Greil, R. (2021). Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer. New England Journal of Medicine, 385(5), 395-405.
Gnant, M., Frantal, S., Pfeiler, G., Steger, G. G., Egle, D., Greil, R., Fitzal, F., Wette, V., ... Singer, C. F. (2022). Long-term outcomes of adjuvant denosumab in breast cancer: Fracture reduction and survival results from 3,425 patients in the randomised, double-blind, placebo-controlled ABCSG-18 trial. Journal of clinical oncology, 40(16_suppl), 507.
Gnant, M., Mlineritsch, B., Luschin-Ebengreuth, G., Stoeger, H., Dubsky, P., Jakesz, R., ... Singer, C. (2011). Long-Term Follow-Up in ABCSG-12: Significantly Improved Overall Survival with Adjuvant Zoledronic Acid in Premenopausal Patients with Endocrine-Receptor-Positive Early Breast Cancer. San Antonio: Cancer Therapy & Research Center at UT Health Science Center. Hentet fra http://cancerres.aacrjournals.org/content/71/24_Supplement/S1-2
Gnant, M., Mlineritsch, B., Schippinger, W., Luschin-Ebengreuth, G., Postlberger, S., Menzel, C., Jakesz, R., Seifert, M., ... Marth, C. (2009). Endocrine therapy plus zoledronic acid in premenopausal breast cancer. New England Journal of Medicine, 360(7), 679-691.
Gnant, M., Mlineritsch, B., Stoeger, H., Luschin-Ebengreuth, G., Heck, D., Menzel, C., Jakesz, R., Seifert, M., ... Greil, R. (2011). Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. The Lancet. Oncology, 12(7), 631-641.
Gnant, M., Sestak, I., Filipits, M., Dowsett, M., Balic, M., Lopez-Knowles, E., Greil, R., Dubsky, P., ... Cuzick, J. (2015). Identifying clinically relevant prognostic subgroups of postmenopausal women with node-positive hormone receptor-positive early-stage breast cancer treated with endocrine therapy: a combined analysis of ABCSG-8 and ATAC using the PAM50 risk of recurrence score and intrinsic subtype. Annals of oncology, 26(8), 1685-91.
Goldhirsch, A., Gelber, R. D., Piccart-Gebhart, M. J., de Azambuja, E., Procter, M., Suter, T. M., Jackisch, C., Cameron, D., ... Baselga, J. (2013). 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): an open-label, randomised controlled trial. Lancet, 382(9897), 1021-8.
Goldhirsch, A., Ingle, J. N., Gelber, R. D., Coates, A. S., Thurlimann, B., & Senn, H. J. (2009). Thresholds for therapies: highlights of the St Gallen International Expert Consensus on the primary therapy of early breast cancer 2009. Annals of oncology, 20(8), 1319-1329.
Goldhirsch, A., Winer, E. P., Coates, A. S., Gelber, R. D., Piccart-Gebhart, M., Thurlimann, B., & Senn, H. J. (2013). Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Annals of oncology, 24(9), 2206-2223.
Goldhirsch, A., Wood, W. C., Coates, A. S., Gelber, R. D., Thurlimann, B., & Senn, H. J. (2011). Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Annals of oncology, 22(8), 1736-1747.
Goldhirsch, A., Wood, W. C., Gelber, R. D., Coates, A. S., Thurlimann, B., & Senn, H. J. (2007). Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007. Annals of oncology, 18(7), 1133-1144.
Goss, P. E., Ingle, J. N., Martino, S., Robert, N. J., Muss, H. B., Livingston, R. B., Davidson, N. E., Perez, E. A., ... Tu, D. (2013). Impact of premenopausal status at breast cancer diagnosis in women entered on the placebo-controlled NCIC CTG MA17 trial of extended adjuvant letrozole. Annals of oncology, 24(2), 355-361.
Goss, P. E., Ingle, J. N., Pritchard, K. I., Robert, N. J., Muss, H., Gralow, J., Gelmon, K., Whelan, T., ... Parulekar, W. R. (2016). Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years. New England Journal of Medicine, 375(3), 209-19.
Gray, R., Rea, D., Handley, K., Bowden, S. J., Perry, P., Earl, H. M., Poole, C. J., Bates, T., ... al., e. (2013). aTTom: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer.. Journal of clinical oncology, 31(suppl - abstr 5)
Greenlee, H., Iribarren, C., Rana, J. S., Cheng, R., Nguyen-Huynh, M., Rillamas-Sun, E., Shi, Z., Laurent, C. A., ... Kwan, M. L. (2022). Risk of Cardiovascular Disease in Women With and Without Breast Cancer: The Pathways Heart Study. Journal of clinical oncology, 40(15), 1647-1658.
Gregory, W., Marshall, H., Bell, R., Cameron, D. A., & Coleman, R. E. (2012). Adjuvant zoledronic acid (ZOL) in postmenopausal women with breast cancer and those rendered postmenopausal: Results of a meta-analysis. Journal of clinical oncology, 30(15 Supplement), 513.
Grogan, M., Tabar, L., Chua, B., Chen, H. H., & Boyages, J. (2001). Estimating the benefits of adjuvant systemic therapy for women with early breast cancer. The British journal of surgery, 88(11), 1513-1518.
Gupta, S., Nair, N. S., Hawaldar, R., Vanmali, V., Parmar, V., Gulia, S., Ghosh, J., Joshi, S., ... Badwe, R. (2023). Abstract GS5-01: Addition of platinum to sequential taxane-anthracycline neoadjuvant chemotherapy in patients with triple-negative breast cancer: A phase III randomized controlled trial. Cancer Research, 83(5 Suppl), GS5-01.
Hanrahan, E. O., Valero, V., Gonzalez-Angulo, A. M., & Hortobagyi, G. N. (2006). Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a,bN0M0): a review of the literature. Journal of clinical oncology, 24(13), 2113-2122.
Harbeck, N., Nitz, U. A., Christgen, M., Kümmel, S., Braun, M., Schumacher, C., Potenberg, J., Tio, J., ... Gluz, O. (2023). De-Escalated Neoadjuvant Trastuzumab-Emtansine With or Without Endocrine Therapy Versus Trastuzumab With Endocrine Therapy in HR+/HER2+ Early Breast Cancer: 5-Year Survival in the WSG-ADAPT-TP Trial. Journal of clinical oncology, 41(22), 3796-3804.
Harbeck, N., Rastogi, P., Martin, M., Tolaney, S. M., Shao, Z. M., Fasching, P. A., Huang, C. S., Jaliffe, G. G., ... O'Shaughnessy, J. (2021). Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study. Annals of oncology, 32(12), 1571-1581.
Harris, L. N., Ismaila, N., McShane, L. M., Andre, F., Collyar, D. E., Gonzalez-Angulo, A. M., Hammond, E. H., Kuderer, N. M., ... Hayes, D. F. (2016). Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline. Journal of clinical oncology, 34(10), 1134-50.
Hayes, D. F., & Rae, J. M. (2020). Pharmacogenomics and Endocrine Therapy in Breast Cancer. Journal of clinical oncology, 38(6), 525-528.
Hayes, D. F., Thor, A. D., Dressler, L. G., Weaver, D., Edgerton, S., Cowan, D., Broadwater, G., Goldstein, L. J., ... Berry, D. A. (2007). HER2 and response to paclitaxel in node-positive breast cancer. New England Journal of Medicine, 357(15), 1496-1506.
He, W., Grassmann, F., Eriksson, M., Eliasson, E., Margolin, S., Thoren, L., Hall, P., & Czene, K. (2020). CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer. Journal of clinical oncology, 38(6), 548-557.
Hugh, J., Hanson, J., Cheang, M. C., Nielsen, T. O., Perou, C. M., Dumontet, C., Reed, J., Krajewska, M., ... Vogel, C. (2009). Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. Journal of clinical oncology, 27(8), 1168-1176.
Iwase, T., Saji, S., Iijima, K., Higaki, K., Ohtani, S., Sato, Y., Hozumi, Y., Hasegawa, Y., ... Mukai, H. (2023). Postoperative Adjuvant Anastrozole for 10 or 5 Years in Patients With Hormone Receptor-Positive Breast Cancer: AERAS, a Randomized Multicenter Open-Label Phase III Trial. Journal of clinical oncology, 41(18), 3329-3338.
Jakesz, R., Jonat, W., Gnant, M., Mittlboeck, M., Greil, R., Tausch, C., Hilfrich, J., Kwasny, W., ... Wolfgang, J. (2005). Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: combined results of ABCSG trial 8 and ARNO 95 trial. Lancet, 366(9484), 455-462.
Joensuu, H., Bono, P., Kataja, V., Alanko, T., Kokko, R., Asola, R., Utriainen, T., Turpeenniemi-Hujanen, T., ... Kellokumpu-Lehtinen, P. L. (2009). Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial. Journal of clinical oncology, 27(34), 5685-92.
Joensuu, H., Fraser, J., Wildiers, H., Huovinen, R., Auvinen, P., Utriainen, M., Nyandoto, P., Villman, K. K., ... Lindman, H. (2018). Effect of Adjuvant Trastuzumab for a Duration of 9 Weeks vs 1 Year With Concomitant Chemotherapy for Early Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: The SOLD Randomized Clinical Trial. JAMA oncology, 4(9), 1199-1206.
Joensuu, H., Kellokumpu-Lehtinen, P. L., Bono, P., Alanko, T., Kataja, V., Asola, R., Utriainen, T., Kokko, R., ... Isola, J. (2006). Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. New England Journal of Medicine, 354(8), 809-20.
Joensuu, H., Kellokumpu-Lehtinen, P. L., Huovinen, R., Jukkola-Vuorinen, A., Tanner, M., Kokko, R., Ahlgren, J., Auvinen, P., ... Lindman, H. (2012). Adjuvant capecitabine, docetaxel, cyclophosphamide, and epirubicin for early breast cancer: final analysis of the randomized FinXX trial. Journal of clinical oncology, 30(1), 11-8.
Johansen, K., Lønning, P. E., Naume, B., Norderhaug, I., Norum, J., Olsen, J. A., Wist, E. (2006). Ny medikamentell behandling av brystkreft - adjuvant behandling med trastuzumab ved tidlig stadium av brystkreft Oslo: Kunnskapssenteret. Hentet fra https://www.fhi.no/publ/eldre/ny-medikamentell-behandling-av-brystkreft.--adjuvant-behandling-med-trastuz/
Johnston, S., Martin, M., O'Shaughnessy, J., Hegg, R., Tolaney, S. M., Guarneri, V., Del Mastro, L., Campone, M., ... Harbeck, N. (2026). Overall survival with abemaciclib in early breast cancer. Annals of oncology, 37(2), 155-165.
Johnston, S. R. D., Harbeck, N., Hegg, R., Toi, M., Martin, M., Shao, Z. M., Zhang, Q. Y., Martinez Rodriguez, J. L., ... Rastogi, P. (2020). Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2-, Node-Positive, High-Risk, Early Breast Cancer (monarchE). Journal of clinical oncology, 38(34), 3987-3998.
Johnston, S. R. D., Toi, M., O'Shaughnessy, J., Rastogi, P., Campone, M., Neven, P., Huang, C. S., Huober, J., ... Martin, M. (2023). Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial. The Lancet. Oncology, 24(1), 77-90.
Jones, S. E., Savin, M. A., Holmes, F. A., O'Shaughnessy, J. A., Blum, J. L., Vukelja, S., McIntyre, K. J., Pippen, J. E., ... Asmar, L. (2006). Phase III trial comparing doxorubicin plus cyclophosphamide with docetaxel plus cyclophosphamide as adjuvant therapy for operable breast cancer. Journal of clinical oncology, 24(34), 5381-7.
Kalinsky, K., Barlow, W. E., Gralow, J. R., Meric-Bernstam, F., Albain, K. S., Hayes, D. F., Lin, N. U., Perez, E. A., ... Hortobagyi, G. N. (2021). 21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer. New England Journal of Medicine, 385(25), 2336-2347.
Klintman, M., Strand, C., Ahlin, C., Beglerbegovic, S., Fjällskog, M. L., Grabau, D., Gudlaugsson, E., Janssen, E. A., ... Ferno, M. (2013). The prognostic value of mitotic activity index (MAI), phosphohistone H3 (PPH3), cyclin B1, cyclin A, and Ki67, alone and in combinations, in node-negative premenopausal breast cancer. PLoS ONE, 8(12), e81902.
Kollias, J., Murphy, C. A., Elston, C. W., Ellis, I. O., Robertson, J. F., & Blamey, R. W. (1999). The prognosis of small primary breast cancers. European journal of cancer, 35(6), 908-12.
Korde, L. A., Somerfield, M. R., Hershman, D. L., & Neoadjuvant Chemotherapy, ,. E. T. a. T. T. f. B. C. G. E. P. (2022). Use of Immune Checkpoint Inhibitor Pembrolizumab in the Treatment of High-Risk, Early-Stage Triple-Negative Breast Cancer: ASCO Guideline Rapid Recommendation Update. Journal of clinical oncology, 40(15), 1696-1698.
Krop, I., Ismaila, N., Andre, F., Bast, R. C., Barlow, W., Collyar, D. E., Hammond, M. E., Kuderer, N. M., ... Stearns, V. (2017). Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American Society of Clinical Oncology Clinical Practice Guideline Focused Update. Journal of clinical oncology, 35(24), 2838-2847.
Lænkholm, A. V., Jensen, M. B., Eriksen, J. O., Rasmussen, B. B., Knoop, A. S., Buckingham, W., Ferree, S., Schaper, C., ... Ejlertsen, B. (2018). PAM50 Risk of Recurrence Score Predicts 10-Year Distant Recurrence in a Comprehensive Danish Cohort of Postmenopausal Women Allocated to 5 Years of Endocrine Therapy for Hormone Receptor-Positive Early Breast Cancer. Journal of clinical oncology, 36(8), 735-740.
Lazzeroni, M., Puntoni, M., Guerrieri-Gonzaga, A., Serrano, D., Boni, L., Buttiron Webber, T., Fava, M., Briata, I. M., ... DeCensi, A. (2023). Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study. Journal of clinical oncology, 41(17), 3116-3121.
Lende, T. H., Janssen, E. A., Gudlaugsson, E., Voorhorst, F., Smaaland, R., van Diest, P., Søiland, H., & Baak, J. P. (2011). In patients younger than age 55 years with lymph node-negative breast cancer, proliferation by mitotic activity index is prognostically superior to adjuvant!. Journal of clinical oncology, 29(7), 852-8.
Leon-Ferre, R. A., Jonas, S. F., Salgado, R., Loi, S., de Jong, V., Carter, J. M., Nielsen, T. O., Leung, S., ... Michiels, S. (2024). Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer. JAMA, 331(13), 1135-1144.
Li, J., Yu, K., Pang, D., Wang, C., Jiang, J., Yang, S., Liu, Y., Fu, P., ... Shao, Z. (2020). Adjuvant Capecitabine With Docetaxel and Cyclophosphamide Plus Epirubicin for Triple-Negative Breast Cancer (CBCSG010): An Open-Label, Randomized, Multicenter, Phase III Trial. Journal of clinical oncology, 38(16), 1774-1784.
Liu, X., Binicy, B., Acs, B., Eriksson Bergman, L., Loibl, S., Gnant, M., Untch, M., Valachis, A., ... Matikas, A. (2025). Prevalence and prognosis of patients with breast cancer eligible for adjuvant abemaciclib or ribociclib: a nationwide population-based study. The Lancet regional health. Europe, 59, 101471.
Lluch, A., Barrios, C. H., Torrecillas, L., Ruiz-Borrego, M., Bines, J., Segalla, J., Guerrero-Zotano, Á., García-Sáenz, J. A., ... Martín, M. (2020). Phase III Trial of Adjuvant Capecitabine After Standard Neo-/Adjuvant Chemotherapy in Patients With Early Triple-Negative Breast Cancer (GEICAM/2003-11_CIBOMA/2004-01). Journal of clinical oncology, 38(3), 203-213.
Loibl, S., André, F., Bachelot, T., Barrios, C. H., Bergh, J., Burstein, H. J., Cardoso, M. J., Carey, L. A., ... Harbeck, N. (2024). Early breast cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Annals of oncology, 35(2), 159-182.
Loibl, S., Jassem, J., Sonnenblick, A., Parlier, D., Winer, E., Bergh, J., Gelber, R. D., Restuccia, E., ... Piccart, M. (2022). VP6-2022: Adjuvant pertuzumab and trastuzumab in patients with early HER-2 positive breast cancer in APHINITY: 8.4 years' follow-up. Annals of oncology, 33(9), 986-987.
Loibl, S., Marmé, F., Martin, M., Untch, M., Bonnefoi, H., Kim, S. B., Bear, H., McCarthy, N., ... von Minckwitz, G. (2021). Palbociclib for Residual High-Risk Invasive HR-Positive and HER2-Negative Early Breast Cancer-The Penelope-B Trial. Journal of clinical oncology, 39(14), 1518-1530.
Loibl, S., O'Shaughnessy, J., Untch, M., Sikov, W. M., Rugo, H. S., McKee, M. D., Huober, J., Golshan, M., ... Geyer, C. E. ,. J. (2018). Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial. The Lancet. Oncology, 19(4), 497-509.
Loibl, S., Schneeweiss, A., Huober, J., Braun, M., Rey, J., Blohmer, J. U., Furlanetto, J., Zahm, D. M., ... Untch, M. (2022). Neoadjuvant durvalumab improves survival in early triple-negative breast cancer independent of pathological complete response. Annals of oncology, 33(11), 1149-1158.
Lund, M., Corn, G., Jensen, M. B., Petersen, T., Dalhoff, K., Ejlertsen, B., Køber, L., Wohlfahrt, J., & Melbye, M. (2024). Ischaemic cardiotoxicity of aromatase inhibitors in postmenopausal patients with early breast cancer in Denmark: a cohort study of real-world data. The Lancet. Oncology, 25(11), 1496-1506.
Mamounas, E. P., Bandos, H., Lembersky, B. C., Jeong, J. H., Geyer, C. E. ,. J., Rastogi, P., Fehrenbacher, L., Graham, M. L., ... Wolmark, N. (2019). Use of letrozole after aromatase inhibitor-based therapy in postmenopausal breast cancer (NRG Oncology/NSABP B-42): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet. Oncology, 20(1), 88-99.
Mamounas, E. P., Bandos, H., Lembersky, B. C., Jeong, J. H., Geyer, C. E., Rastogi, P., Fehrenbacher, L., Graham, M. L., ... Wolmark, N. (2020). Abstract GS4-01: Ten-year results from NRG Oncology/NSABP B-42: A randomized, double-blinded, placebo-controlled clinical trial of extended adjuvant endocrine therapy with letrozole (L) in postmenopausal women with hormone-receptor+ breast cancer (BC) who have completed previous adjuvant therapy with an aromatase inhibitor (AI). Cancer Research, 80(4 Suppl), GS4-01.
Martin, M., Holmes, F. A., Ejlertsen, B., Delaloge, S., Moy, B., Iwata, H., von Minckwitz, G., Chia, S. K. L., ... Chan, A. (2017). Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet. Oncology, 18(12), 1688-1700.
Martin, M., Pienkowski, T., Mackey, J., Pawlicki, M., Guastalla, J. P., Weaver, C., Tomiak, E., Al-Tweigeri, T., ... Vogel, C. (2005). Adjuvant docetaxel for node-positive breast cancer. New England Journal of Medicine, 352(22), 2302-2313.
Martín, M., Ruiz Simón, A., Ruiz Borrego, M., Ribelles, N., Rodríguez-Lescure, Á., Muñoz-Mateu, M., González, S., Margelí Vila, M., ... Lluch, A. (2015). Epirubicin Plus Cyclophosphamide Followed by Docetaxel Versus Epirubicin Plus Docetaxel Followed by Capecitabine As Adjuvant Therapy for Node-Positive Early Breast Cancer: Results From the GEICAM/2003-10 Study. Journal of clinical oncology, 33(32), 3788-95.
Masuda, N., Lee, S. J., Ohtani, S., Im, Y. H., Lee, E. S., Yokota, I., Kuroi, K., Im, S. A., ... Toi, M. (2017). Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy. New England Journal of Medicine, 376(22), 2147-2159.
Mayer, I. A., Zhao, F., Arteaga, C. L., Symmans, W. F., Park, B. H., Burnette, B. L., Tevaarwerk, A. J., Garcia, S. F., ... Miller, K. D. (2021). Randomized Phase III Postoperative Trial of Platinum-Based Chemotherapy Versus Capecitabine in Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy: ECOG-ACRIN EA1131. Journal of clinical oncology, 39(23), 2539-2551.
Michel, L. L., Schwarz, D., Romar, P., Feisst, M., Hamberger, D., Priester, A., Kurre, E., Klein, E., ... Schneeweiss, A. (2025). Efficacy of Hand Cooling and Compression in Preventing Taxane-Induced Neuropathy: The POLAR Randomized Clinical Trial. JAMA oncology, 11(4), 408-415.
Mittendorf, E. A., Jeruss, J. S., Tucker, S. L., Kolli, A., Newman, L. A., Gonzalez-Angulo, A. M., Buchholz, T. A., Sahin, A. A., ... Hunt, K. K. (2011). Validation of a novel staging system for disease-specific survival in patients with breast cancer treated with neoadjuvant chemotherapy. Journal of clinical oncology, 29(15), 1956-62.
Mittendorf, E. A., Zhang, H., Barrios, C. H., Saji, S., Jung, K. H., Hegg, R., Koehler, A., Sohn, J., ... Harbeck, N. (2020). Neoadjuvant atezolizumab in combination with sequential nab-paclitaxel and anthracycline-based chemotherapy versus placebo and chemotherapy in patients with early-stage triple-negative breast cancer (IMpassion031): a randomised, double-blind, phase 3 trial. Lancet, 396(10257), 1090-1100.
Möbus, V., Diel, I. J., Elling, D., Harbeck, N., Jackisch, C., Thomssen, C., ... Untch, M. (2011). GAIN Study: A Phase III Trial To Compare ETC vs. EC-TX and Ibandronate vs. Observation in Patients with Node-Positive Primary Breast Cancer – 1st Interim Efficacy Analysis. San Antonio: Cancer Therapy & Research Center at UT Health Science Center. Hentet fra http://cancerres.aacrjournals.org/content/71/24_Supplement/S2-4
Mouridsen, H., Giobbie-Hurder, A., Goldhirsch, A., Thurlimann, B., Paridaens, R., Smith, I., Mauriac, L., Forbes, J. F., ... Coates, A. S. (2009). Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer. New England Journal of Medicine, 361(8), 766-776.
Muss, H. B., Biganzoli, L., Sargent, D. J., & Aapro, M. (2007). Adjuvant therapy in the elderly: making the right decision. Journal of clinical oncology, 25(14), 1870-1875.
Muss, H. B., Tu, D., Ingle, J. N., Martino, S., Robert, N. J., Pater, J. L., Whelan, T. J., Palmer, M. J., ... Goss, P. E. (2008). Efficacy, toxicity, and quality of life in older women with early-stage breast cancer treated with letrozole or placebo after 5 years of tamoxifen: NCIC CTG intergroup trial MA.17. Journal of clinical oncology, 26(12), 1956-1964.
Natori, A., Ethier, J. L., Amir, E., & Cescon, D. W. (2017). Capecitabine in early breast cancer: A meta-analysis of randomised controlled trials. European journal of cancer, 77, 40-47.
Nielsen, T. O., Leung, S. C. Y., Rimm, D. L., Dodson, A., Acs, B., Badve, S., Denkert, C., Ellis, M. J., ... Hayes, D. F. (2021). Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group. Journal of the National Cancer Institute, 113(7), 808-819.
Nielsen, T. O., Parker, J. S., Leung, S., Voduc, D., Ebbert, M., Vickery, T., Davies, S. R., Snider, J., ... Ellis, M. J. (2010). A comparison of PAM50 intrinsic subtyping with immunohistochemistry and clinical prognostic factors in tamoxifen-treated estrogen receptor-positive breast cancer. Clinical cancer research, 16(21), 5222-32.
Nitz, U., Gluz, O., Clemens, M., Malter, W., Reimer, T., Nuding, B., Aktas, B., Stefek, A., ... Harbeck, N. (2019). West German Study PlanB Trial: Adjuvant Four Cycles of Epirubicin and Cyclophosphamide Plus Docetaxel Versus Six Cycles of Docetaxel and Cyclophosphamide in HER2-Negative Early Breast Cancer. Journal of clinical oncology, 37(10), 799-808.
Norsk bryst cancer gruppe (2022). Algoritme for kontroll av LVEF under anti-HER2 behandling og kontinuering/diskontinuering av behandlingen Oslo: NBCG. Hentet fra https://nbcg.no/behandlingsskjemaer/medikamentell-behandling/
Ohnstad, H. O., Blix, E. S., Akslen, L. A., Gilje, B., Raj, S. X., Skjerven, H., Borgen, E., Janssen, E. A. M., ... Naume, B. (2024). Impact of Prosigna test on adjuvant treatment decision in lymph node-negative early breast cancer-a prospective national multicentre study (EMIT-1). ESMO open, 9(6), 103475.
Ohnstad, H. O., Borgen, E., Falk, R. S., Lien, T. G., Aaserud, M., Sveli, M. A. T., Kyte, J. A., Kristensen, V. N., ... Naume, B. (2017). Prognostic value of PAM50 and risk of recurrence score in patients with early-stage breast cancer with long-term follow-up. Breast cancer research, 19(1), 120.
Pagani, O., Francis, P. A., Fleming, G. F., Walley, B. A., Viale, G., Colleoni, M., Láng, I., Gómez, H. L., ... Regan, M. M. (2020). Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT. Journal of clinical oncology, 38(12), 1293-1303.
Pagani, O., Regan, M. M., Walley, B. A., Fleming, G. F., Colleoni, M., Lang, I., Gomez, H. L., Tondini, C., ... Francis, P. A. (2014). Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. New England Journal of Medicine, 371(2), 107-18.
Pagani, O., Walley, B. A., Fleming, G. F., Colleoni, M., Láng, I., Gomez, H. L., Tondini, C., Burstein, H. J., ... Francis, P. A. (2023). Adjuvant Exemestane With Ovarian Suppression in Premenopausal Breast Cancer: Long-Term Follow-Up of the Combined TEXT and SOFT Trials. Journal of clinical oncology, 41(7), 1376-1382.
Paik, S., Tang, G., Shak, S., Kim, C., Baker, J., Kim, W., Cronin, M., Baehner, F. L., ... Wolmark, N. (2006). Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. Journal of clinical oncology, 24(23), 3726-34.
Pan, H., Gray, R., Braybrooke, J., Davies, C., Taylor, C., McGale, P., Peto, R., Pritchard, K. I., ... Hayes, D. F. (2017). 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years. New England Journal of Medicine, 377(19), 1836-1846.
Paterson, A. H. G., Anderson, S. J., Lembersky, B. C., Fehrenbacher, L., Falkson, C. I., King, K. M., ... Weir, L. M. (2011). NSABP Protocol B-34: A Clinical Trial Comparing Adjuvant Clodronate vs. Placebo in Early Stage Breast Cancer Patients Receiving Systemic Chemotherapy and/or Tamoxifen or No Therapy – Final Analysis. San Antonio: Cancer Therapy & Research Center at UT Health Science Center. Hentet fra http://cancerres.aacrjournals.org/content/71/24_Supplement/S2-3
Pathak, N., Sharma, A., Elavarasi, A., Sankar, J., Deo, S. V. S., Sharma, D. N., Mathur, S., Kumar, S., ... Batra, A. (2022). Moment of truth-adding carboplatin to neoadjuvant/adjuvant chemotherapy in triple negative breast cancer improves overall survival: An individual participant data and trial-level Meta-analysis. Breast, 64, 7-18.
Penault-Llorca, F., Andre, F., Sagan, C., Lacroix-Triki, M., Denoux, Y., Verriele, V., Jacquemier, J., Baranzelli, M. C., ... Roche, H. (2009). Ki67 expression and docetaxel efficacy in patients with estrogen receptor-positive breast cancer. Journal of clinical oncology, 27(17), 2809-2815.
Perez, E. A., Romond, E. H., Suman, V. J., Jeong, J. H., Sledge, G., Geyer, C. E. ,. J., Martino, S., Rastogi, P., ... Wolmark, N. (2014). Trastuzumab plus adjuvant chemotherapy for human epidermal growth factor receptor 2-positive breast cancer: planned joint analysis of overall survival from NSABP B-31 and NCCTG N9831. Journal of clinical oncology, 32(33), 3744-52.
Perez, E. A., Suman, V. J., Davidson, N. E., Gralow, J. R., Kaufman, P. A., Visscher, D. W., Chen, B., Ingle, J. N., ... Jenkins, R. B. (2011). Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancer. Journal of clinical oncology, 29(34), 4491-4497.
Peto, R., Davies, C., Godwin, J., Gray, R., Pan, H. C., Clarke, M., Cutter, D., Darby, S., ... Pritchard, K. (2012). Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet, 379(9814), 432-444.
Petruolo, O. A., Pilewskie, M., Patil, S., Barrio, A. V., Stempel, M., Wen, H. Y., & Morrow, M. (2017). Standard Pathologic Features Can Be Used to Identify a Subset of Estrogen Receptor-Positive, HER2 Negative Patients Likely to Benefit from Neoadjuvant Chemotherapy. Annals of surgical oncology, 24(9), 2556-2562.
Piccart, M., Procter, M., Fumagalli, D., Azambuja, E. d., Clark, E., Ewer, M. S., Restuccia, E., Jerusalem, G., ... Investigators (2021). Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer in the APHINITY Trial: 6 Years' Follow-Up. Journal of clinical oncology, 39(13), 1448-1457.
Piccart, M., van 't Veer, L. J., Poncet, C., Lopes Cardozo, J. M. N., Delaloge, S., Pierga, J. Y., Vuylsteke, P., Brain, E., ... Rutgers, E. J. T. (2021). 70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age. The Lancet. Oncology, 22(4), 476-488.
Piccart, M. J., de Valeriola, D., Dal Lago, L., de Azambuja, E., Demonty, G., Lebrun, F., Bernard-Marty, C., Colozza, M., & Cufer, T. (2005). Adjuvant chemotherapy in 2005: standards and beyond. Breast, 14(6), 439-445.
Piccart-Gebhart, M. J., Procter, M., Leyland-Jones, B., Goldhirsch, A., Untch, M., Smith, I., Gianni, L., Baselga, J., ... Gelber, R. D. (2005). Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. New England Journal of Medicine, 353(16), 1659-1672.
Pivot, X., Romieu, G., Debled, M., Pierga, J. Y., Kerbrat, P., Bachelot, T., Lortholary, A., Espie, M., ... Kramar, A. (2013). 6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 trial. The Lancet. Oncology, 14(8), 741-8.
Poggio, F., Bruzzone, M., Ceppi, M., Ponde, N. F., La Valle, G., Del Mastro, L., de Azambuja, E., & Lambertini, M. (2018). Platinum-based neoadjuvant chemotherapy in triple-negative breast cancer: a systematic review and meta-analysis. Annals of oncology, 29(7), 1497-1508.
Quiet, C. A., Ferguson, D. J., Weichselbaum, R. R., & Hellman, S. (1995). Natural history of node-negative breast cancer: a study of 826 patients with long-term follow-up. Journal of clinical oncology, 13(5), 1144-1151.
Rastogi, P., Anderson, S. J., Bear, H. D., Geyer, C. E., Kahlenberg, M. S., Robidoux, A., Margolese, R. G., Hoehn, J. L., ... Wolmark, N. (2008). Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. Journal of clinical oncology, 26(5), 778-785.
Rastogi, P., O'Shaughnessy, J., Martin, M., Boyle, F., Cortes, J., Rugo, H. S., Goetz, M. P., Hamilton, E. P., ... Johnston, S. (2024). Adjuvant Abemaciclib Plus Endocrine Therapy for Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative, High-Risk Early Breast Cancer: Results From a Preplanned monarchE Overall Survival Interim Analysis, Including 5-Year Efficacy Outcomes. Journal of clinical oncology, 42(9), 987-993.
Reed, W., Hannisdal, E., Boehler, P. J., Gundersen, S., Host, H., & Marthin, J. (2000). The prognostic value of p53 and c-erb B-2 immunostaining is overrated for patients with lymph node negative breast carcinoma: a multivariate analysis of prognostic factors in 613 patients with a follow-up of 14-30 years. Cancer, 88(4), 804-813.
Regan, M. M., Neven, P., Giobbie-Hurder, A., Goldhirsch, A., Ejlertsen, B., Mauriac, L., Forbes, J. F., Smith, I., ... Thurlimann, B. (2011). Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8.1 years median follow-up. The Lancet. Oncology, 12(12), 1101-1108.
Romond, E. H., Perez, E. A., Bryant, J., Suman, V. J., Geyer, C. E. ,., Davidson, N. E., Tan-Chiu, E., Martino, S., ... Wolmark, N. (2005). Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. New England Journal of Medicine, 353(16), 1673-1684.
Rosen, P. P., Groshen, S., Saigo, P. E., Kinne, D. W., & Hellman, S. (1989). Pathological prognostic factors in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma: a study of 644 patients with median follow-up of 18 years. Journal of clinical oncology, 7(9), 1239-51.
Rosen, P. R., Groshen, S., Saigo, P. E., Kinne, D. W., & Hellman, S. (1989). A long-term follow-up study of survival in stage I (T1N0M0) and stage II (T1N1M0) breast carcinoma. Journal of clinical oncology, 7(3), 355-66.
Rugo, H. S., O'Shaughnessy, J., Boyle, F., Toi, M., Broom, R., Blancas, I., Gumus, M., Yamashita, T., ... Tolaney, S. M. (2022). Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: safety and patient-reported outcomes from the monarchE study. Annals of oncology, 33(6), 616-627.
Ruhstaller, T., Giobbie-Hurder, A., Colleoni, M., Jensen, M. B., Ejlertsen, B., de Azambuja, E., Neven, P., Láng, I., ... Regan, M. M. (2019). Adjuvant Letrozole and Tamoxifen Alone or Sequentially for Postmenopausal Women With Hormone Receptor-Positive Breast Cancer: Long-Term Follow-Up of the BIG 1-98 Trial. Journal of clinical oncology, 37(2), 105-114.
Sawaki, M., Taira, N., Uemura, Y., Saito, T., Baba, S., Kobayashi, K., Kawashima, H., Tsuneizumi, M., ... Mukai, H. (2020). Randomized Controlled Trial of Trastuzumab With or Without Chemotherapy for HER2-Positive Early Breast Cancer in Older Patients. Journal of clinical oncology, 38(32), 3743-3752.
Schmid, P., Cortes, J., Dent, R., McArthur, H., Pusztai, L., Kümmel, S., Denkert, C., Park, Y. H., ... O'Shaughnessy, J. (2024). Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer. New England Journal of Medicine, 391(21), 1981-1991.
Schmid, P., Cortes, J., Dent, R., Pusztai, L., McArthur, H., Kümmel, S., Bergh, J., Denkert, C., ... O'Shaughnessy, J. (2022). Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer. New England Journal of Medicine, 386(6), 556-567.
Sestak, I., Dowsett, M., Zabaglo, L., Lopez-Knowles, E., Ferree, S., Cowens, J. W., & Cuzick, J. (2013). Factors predicting late recurrence for estrogen receptor-positive breast cancer. Journal of the National Cancer Institute, 105(19), 1504-11.
Sikov, W. M., Berry, D. A., Perou, C. M., Singh, B., Cirrincione, C. T., Tolaney, S. M., Kuzma, C. S., Pluard, T. J., ... Winer, E. P. (2015). Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance). Journal of clinical oncology, 33(1), 13-21.
Silver, D. P., Richardson, A. L., Eklund, A. C., Wang, Z. C., Szallasi, Z., Li, Q., Juul, N., Leong, C. O., ... Garber, J. E. (2010). Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer. Journal of clinical oncology, 28(7), 1145-53.
Slamon, D., Eiermann, W., Robert, N., Giermek, J., Martin, M., Jasiowka, M., Mackey, J., Chan, A., ... Investigators, O. B. o. t. B. (2016). Abstract S5-04: Ten year follow-up of BCIRG-006 comparing doxorubicin plus cyclophosphamide followed by docetaxel (AC→T) with doxorubicin plus cyclophosphamide followed by docetaxel and trastuzumab (AC→TH) with docetaxel, carboplatin and trastuzumab (TCH) in HER2+ early breast cancer. Cancer Research, 76(4_Suppl), S5-04.
Slamon, D., Eiermann, W., Robert, N., Pienkowski, T., Martin, M., Press, M., Mackey, J., Glaspy, J., ... Crown, J. (2011). Adjuvant trastuzumab in HER2-positive breast cancer. New England Journal of Medicine, 365(14), 1273-1283.
Slamon, D., Lipatov, O., Nowecki, Z., McAndrew, N., Kukielka-Budny, B., Stroyakovskiy, D., Yardley, D. A., Huang, C. S., ... Hortobagyi, G. (2024). Ribociclib plus Endocrine Therapy in Early Breast Cancer. New England Journal of Medicine, 390(12), 1080-1091.
Slamon, D. J., Clark, G. M., Wong, S. G., Levin, W. J., Ullrich, A., & McGuire, W. L. (1987). Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science, 235(4785), 177-182.
Slamon, D. J., Godolphin, W., Jones, L. A., Holt, J. A., Wong, S. G., Keith, D. E., Levin, W. J., Stuart, S. G., ... Ullrich, A. (1989). Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science, 244(4905), 707-712.
Sparano, J. A., Gray, R. J., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E. ,. J., Dees, E. C., ... Sledge, G. W. ,. J. (2018). Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. New England Journal of Medicine, 379(2), 111-121.
Sparano, J. A., Gray, R. J., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E. ,. J., Dees, E. C., ... Sledge, G. W. (2015). Prospective Validation of a 21-Gene Expression Assay in Breast Cancer. New England Journal of Medicine, 373(21), 2005-14.
Sparano, J. A., Gray, R. J., Ravdin, P. M., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E. ,. J., ... Sledge, G. W. ,. J. (2019). Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer. New England Journal of Medicine, 380(25), 2395-2405.
Sparano, J. A., Wang, M., Martino, S., Jones, V., Perez, E. A., Saphner, T., Wolff, A. C., Sledge, G. W. ,. J., ... Davidson, N. E. (2008). Weekly paclitaxel in the adjuvant treatment of breast cancer. New England Journal of Medicine, 358(16), 1663-71.
Spring, L. M., Gupta, A., Reynolds, K. L., Gadd, M. A., Ellisen, L. W., Isakoff, S. J., Moy, B., & Bardia, A. (2016). Neoadjuvant Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-analysis. JAMA oncology, 2(11), 1477-1486.
Steenbruggen, T. G., van Werkhoven, E., van Ramshorst, M. S., Dezentjé, V. O., Kok, M., Linn, S. C., Siesling, S., & Sonke, G. S. (2020). Adjuvant chemotherapy in small node-negative triple-negative breast cancer. European journal of cancer, 135, 66-74.
Swain, S. M., Jeong, J. H., Geyer, C. E. ,. J., Costantino, J. P., Pajon, E. R., Fehrenbacher, L., Atkins, J. N., Polikoff, J., ... Wolmark, N. (2010). Longer therapy, iatrogenic amenorrhea, and survival in early breast cancer. New England Journal of Medicine, 362(22), 2053-65.
Tamura, K., Imamura, C. K., Takano, T., Saji, S., Yamanaka, T., Yonemori, K., Takahashi, M., Tsurutani, J., ... Tanigawara, Y. (2020). CYP2D6 Genotype-Guided Tamoxifen Dosing in Hormone Receptor-Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study. Journal of clinical oncology, 38(6), 558-566.
Tarantino, P., Leone, J., Vallejo, C. T., Freedman, R. A., Waks, A. G., Martínez-Sáez, O., Garrido-Castro, A., Lynce, F., ... Leone, J. P. (2024). Prognosis and treatment outcomes for patients with stage IA triple-negative breast cancer. NPJ breast cancer, 10(1), 26.
Thor, A. D., Berry, D. A., Budman, D. R., Muss, H. B., Kute, T., Henderson, I. C., Barcos, M., Cirrincione, C., ... Liu, E. T. (1998). erbB-2, p53, and efficacy of adjuvant therapy in lymph node-positive breast cancer. Journal of the National Cancer Institute, 90(18), 1346-1360.
Tjan-Heijnen, V. C. G., van Hellemond, I. E. G., Peer, P. G. M., Swinkels, A. C. P., Smorenburg, C. H., van der Sangen, M. J. C., Kroep, J. R., De Graaf, H., ... Seynaeve, C. M. (2017). Extended adjuvant aromatase inhibition after sequential endocrine therapy (DATA): a randomised, phase 3 trial. The Lancet. Oncology, 18(11), 1502-1511.
Tolaney, S. M., Barry, W. T., Dang, C. T., Yardley, D. A., Moy, B., Marcom, P. K., Albain, K. S., Rugo, H. S., ... Winer, E. P. (2015). Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer. New England Journal of Medicine, 372(2), 134-41.
Tolaney, S. M., Guo, H., Pernas, S., Barry, W. T., Dillon, D. A., Ritterhouse, L., Schneider, B. P., Shen, F., ... Winer, E. P. (2019). Seven-Year Follow-Up Analysis of Adjuvant Paclitaxel and Trastuzumab Trial for Node-Negative, Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer. Journal of clinical oncology, 37(22), 1868-1875.
Tolaney, S. M., Tarantino, P., Graham, N., Tayob, N., Parè, L., Villacampa, G., Dang, C. T., Yardley, D. A., ... Winer, E. P. (2023). Adjuvant paclitaxel and trastuzumab for node-negative, HER2-positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial. The Lancet. Oncology, 24(3), 273-285.
Tolaney, S. M., Tayob, N., Dang, C., Yardley, D. A., Isakoff, S. J., Valero, V., Faggen, M., Mulvey, T., ... Krop, I. (2021). Adjuvant Trastuzumab Emtansine Versus Paclitaxel in Combination With Trastuzumab for Stage I HER2-Positive Breast Cancer (ATEMPT): A Randomized Clinical Trial. Journal of clinical oncology, 39(21), 2375-2385.
Trudeau, M., Charbonneau, F., Gelmon, K., Laing, K., Latreille, J., Mackey, J., McLeod, D., Pritchard, K., ... Verma, S. (2005). Selection of adjuvant chemotherapy for treatment of node-positive breast cancer. The Lancet. Oncology, 6(11), 886-898.
Tutt, A. N. J., Garber, J. E., Kaufman, B., Viale, G., Fumagalli, D., Rastogi, P., Gelber, R. D., de Azambuja, E., ... Geyer, C. E. ,. J. (2021). Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer. New England Journal of Medicine, 384(25), 2394-2405.
Untch, M., Jackisch, C., Schneeweiss, A., Schmatloch, S., Aktas, B., Denkert, C., Schem, C., Wiebringhaus, H., ... Loibl, S. (2019). NAB-Paclitaxel Improves Disease-Free Survival in Early Breast Cancer: GBG 69-GeparSepto. Journal of clinical oncology, 37(25), 2226-2234.
Valenza, C., Zheng, Y., Milano, M., Giordano, E., Guidi, L., Giachetti, P. P. M. B., Boldrini, L., Castellano, G., ... Partridge, A. H. (2025). Extended endocrine therapy after 5 years of adjuvant LHRH-agonist in premenopausal patients with node-positive hormone receptor (HR)-positive early breast cancer. Journal of Clinical Oncology, 43(16 suppl), 537.
van der Voort, A., van Ramshorst, M. S., van Werkhoven, E. D., Mandjes, I. A., Kemper, I., Vulink, A. J., Oving, I. M., Honkoop, A. H., ... Sonke, G. S. (2021). Three-Year Follow-up of Neoadjuvant Chemotherapy With or Without Anthracyclines in the Presence of Dual ERBB2 Blockade in Patients With ERBB2-Positive Breast Cancer: A Secondary Analysis of the TRAIN-2 Randomized, Phase 3 Trial. JAMA oncology, 7(7), 978-984.
van Hellemond, I. E. G., Vriens, I. J. H., Peer, P. G. M., Swinkels, A. C. P., Smorenburg, C. H., Seynaeve, C. M., van der Sangen, M. J. C., Kroep, J. R., ... Tjan-Heijnen, V. C. G. (2017). Ovarian Function Recovery During Anastrozole in Breast Cancer Patients With Chemotherapy-Induced Ovarian Function Failure. Journal of the National Cancer Institute, 109(12)
van Mackelenbergh, M., Seither, F., Möbus, V., Shaugnessy, J., Martin, M., Joenssuu, H., Untch, M., Nitz, U., ... Loibl, S. (2020). Abstract GS1-07: Effects of capecitabine as part of neo-/adjuvant chemotherapy. A meta-analysis of individual patient data from 12 randomized trials including 15,457 patients. Cancer Research, 80(4 Suppl), GS1-07.
Varshavsky-Yanovsky, A. N., & Goldstein, L. J. (2020). Role of Capecitabine in Early Breast Cancer. Journal of clinical oncology, 38(3), 179-182.
Venturini, M., Del Mastro, L., Aitini, E., Baldini, E., Caroti, C., Contu, A., Testore, F., Brema, F., ... Bruzzi, P. (2005). Dose-dense adjuvant chemotherapy in early breast cancer patients: results from a randomized trial. Journal of the National Cancer Institute, 97(23), 1724-1733.
Vidal, L., Ben-Aharon, I., Shulamith, R., Yerushalmi, R., Sulkes, A., & Stemmer, S. M. (2012). Bisphosphonates in the adjuvant setting of breast cancer therapy: Effect on survival--A systematic review and meta-analysis. Journal of clinical oncology, 30(15 Supplement), 548.
von Minckwitz, G., Huang, C. S., Mano, M. S., Loibl, S., Mamounas, E. P., Untch, M., Wolmark, N., Rastogi, P., ... Geyer, C. E. ,. J. (2019). Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer. New England Journal of Medicine, 380(7), 617-628.
von Minckwitz, G., Procter, M., de Azambuja, E., Zardavas, D., Benyunes, M., Viale, G., Suter, T., Arahmani, A., ... Baselga, J. (2017). Adjuvant Pertuzumab and Trastuzumab in Early HER2-Positive Breast Cancer. New England Journal of Medicine, 377(2), 122-131.
von Minckwitz, G., Schneeweiss, A., Loibl, S., Salat, C., Denkert, C., Rezai, M., Blohmer, J. U., Jackisch, C., ... Untch, M. (2014). Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial. The Lancet. Oncology, 15(7), 747-56.
Wirapati, P., Sotiriou, C., Kunkel, S., Farmer, P., Pradervand, S., Haibe-Kains, B., Desmedt, C., Ignatiadis, M., ... Delorenzi, M. (2008). Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast cancer research, 10(4), R65.
Yu, K. D., Liu, X. Y., Chen, L., Mo, M., Wu, J., Liu, G. Y., Di, G. H., Verschraegen, C., ... Shao, Z. M. (2021). Anthracycline-free or short-term regimen as adjuvant chemotherapy for operable breast cancer: A phase III randomized non-inferiority trial. The Lancet regional health. Western Pacific, 11, 100158.
Yu, K. D., Ye, F. G., He, M., Fan, L., Ma, D., Mo, M., Wu, J., Liu, G. Y., ... Shao, Z. M. (2020). Effect of Adjuvant Paclitaxel and Carboplatin on Survival in Women With Triple-Negative Breast Cancer: A Phase 3 Randomized Clinical Trial. JAMA oncology, 6(9), 1390-1396.
Siste faglige endring: 23. mars 2026