WHOs klassifisering fra 2022 innføres. Akselerert fase er avskaffet. I blastfase er grensen satt til 20% myeloblaster og >5% lymfoblaster i PB eller BM Dette betyr at resultater fra tidligere studier på blastfase og akselerert fase ikke nødvendigvis er fullt dekkende for pasienter som klassifiseres etter den nye definisjonen
Start med Tyrosin kinase hemmer (TKI) på morfologisk sterk mistanke om kronisk myelogen leukemi (KML). Ikke bruk hydroxyurea eller allopurinol. Pasientene bør oppfordres til rikelig væskeinntak første måned.
Asciminib er innført av Nye metoder til behandling av Philadelphia- kromosom-positiv kronisk myelogen leukemi i kronisk fase (Ph+KML-KF) som tidligere er behandlet med to eller flere tyrosinkinasehemmere (TKIer), hvor rimeligere tyrosinkinasehemmere ikke er egnet.
Abruzzese, E.,
Mauro, M.,
Apperley, J.,
& Chelysheva, E.
(2020).Tyrosine kinase inhibitors and pregnancy in chronic myeloid leukemia: opinion, evidence, and recommendations.Therapeutic advances in hematology,11, 2.04062072096612E15.
Apperley, J. F.
(2007).Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia.Lancet Oncology,8(11), 1018-29.
Baccarani, M.,
Deininger, M. W.,
Rosti, G.,
Hochhaus, A.,
Soverini, S.,
Apperley, J. F.,
... Hehlmann, R.
(2013).European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013.Blood,122(6), 872-84.
Branford, S.,
Kim, D. D. H.,
Apperley, J. F.,
Eide, C. A.,
Mustjoki, S.,
Ong, S. T.,
... Hughes, T. P.
(2019).Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia.Leukemia,33(8), 1835-1850.
Brioli, A.,
Lomaia, E.,
Fabisch, C.,
Sacha, T.,
Klamová, H.,
Morozova, E.,
... Lauseker, M.
(2022).Treatment and Disease Characteristics of Chronic Myeloid Leukemia in Blast Crisis: The European Leukemianet Blast Crisis Registry.Blood,140(Supplement 1), 818-820.
Copland, M.,
Slade, D.,
McIlroy, G.,
Horne, G.,
Byrne, J. L.,
Rothwell, K.,
... Yap, C.
(2022).Ponatinib with fludarabine, cytarabine, idarubicin, and granulocyte colony-stimulating factor chemotherapy for patients with blast-phase chronic myeloid leukaemia (MATCHPOINT): a single-arm, multicentre, phase 1/2 trial.The Lancet. Haematology,9(2), e121-e132.
Cortes, J.,
Apperley, J.,
Lomaia, E.,
Moiraghi, B.,
Undurraga Sutton, M.,
Pavlovsky, C.,
... Deininger, M.
(2021).Ponatinib dose-ranging study in chronic-phase chronic myeloid leukemia: a randomized, open-label phase 2 clinical trial.Blood,138(21), 2042-2050.
Cortes, J.,
Lomaia, E.,
Turkina, A.,
Moiraghi, B.,
Sutton, M. U.,
Pavlovsky, C.,
Deininger, M.
(2020).Interim Analysis from the OPTIC Trial - A Dose-Ranging Study of 3 Starting Doses of PonatinibMøtepresentasjon på 25th EHA Annual Congress: "Unfolding the future!", June 11-21, 2020:Hentet fra https://library.ehaweb.org/eha/2020/eha25th/294992/
Cortes, J. E.,
Gambacorti-Passerini, C.,
Deininger, M. W.,
Mauro, M. J.,
Chuah, C.,
Kim, D. W.,
... Brummendorf, T. H.
(2018).Bosutinib Versus Imatinib for Newly Diagnosed Chronic Myeloid Leukemia: Results From the Randomized BFORE Trial.Journal of Clinical Oncology,36(3), 231-237.
Cortes, J. E.,
Kim, D. W.,
Kantarjian, H. M.,
Brummendorf, T. H.,
Dyagil, I.,
Griskevicius, L.,
... Gambacorti-Passerini, C.
(2012).Bosutinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: results from the BELA trial.Journal of Clinical Oncology,30(28), 3486-3492.
Cortes, J. E.,
Kim, D. W.,
Pinilla-Ibarz, J.,
le Coutre, P. D.,
Paquette, R.,
Chuah, C.,
... Kantarjian, H. M.
(2018).Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial.Blood,132(4), 393-404.
Cross, N. C.,
White, H. E.,
Müller, M. C.,
Saglio, G.,
& Hochhaus, A.
(2012).Standardized definitions of molecular response in chronic myeloid leukemia.Leukemia,26(10), 2172-5.
de Lavallade, H.,
Apperley, J. F.,
Khorashad, J. S.,
Milojkovic, D.,
Reid, A. G.,
Bua, M.,
... Marin, D.
(2008).Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis.Journal of Clinical Oncology,26(20), 3358-63.
Fabarius, A.,
Leitner, A.,
Hochhaus, A.,
Muller, M. C.,
Hanfstein, B.,
Haferlach, C.,
... Hehlmann, R.
(2011).Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV.Blood,118(26), 6760-6768.
Gratwohl, A.,
Stern, M.,
Brand, R.,
Apperley, J.,
Baldomero, H.,
de Witte, T.,
... European Group for Blood Marrow Transplantation the European Leukemia Net
(2009).Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis.Cancer,115(20), 4715-26.
Hochhaus, A.,
Baccarani, M.,
Silver, R. T.,
Schiffer, C.,
Apperley, J. F.,
Cervantes, F.,
... Hehlmann, R.
(2020).European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia.Leukemia,34(4), 966-984.
Hochhaus, A.,
Gambacorti-Passerini, C.,
Abboud, C.,
Gjertsen, B. T.,
Brümmendorf, T. H.,
Smith, B. D.,
... Giles, F. J.
(2020).Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study.Leukemia,34(8), 2125-2137.
Hochhaus, A.,
O'Brien, S. G.,
Guilhot, F.,
Druker, B. J.,
Branford, S.,
Foroni, L.,
... Iris Investigators
(2009).Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemia.Leukemia,23(6), 1054-61.
Hughes, T. P.,
Hochhaus, A.,
Branford, S.,
Muller, M. C.,
Kaeda, J. S.,
Foroni, L.,
... Iris investigators
(2010).Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS).Blood,116(19), 3758-65.
Hughes, T. P.,
Mauro, M. J.,
Cortes, J. E.,
Minami, H.,
Rea, D.,
DeAngelo, D. J.,
... Kim, D. W.
(2019).Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure.New England Journal of Medicine,381(24), 2315-2326.
Jabbour, E.,
Kantarjian, H.,
Ravandi, F.,
Thomas, D.,
Huang, X.,
Faderl, S.,
... O'Brien, S.
(2015).Combination of hyper-CVAD with ponatinib as first-line therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia: a single-centre, phase 2 study.Lancet Oncology,16(15), 1547-1555.
Jabbour, E.,
Sasaki, K.,
Haddad, F. G.,
Issa, G. C.,
Skinner, J.,
Dellasala, S.,
... Kantarjian, H.
(2022).Low-dose dasatinib 50 mg/day versus standard-dose dasatinib 100 mg/day as frontline therapy in chronic myeloid leukemia in chronic phase: A propensity score analysis.American journal of hematology,97(11), 1413-1418.
Kantarjian, H. M.,
Shah, N. P.,
Cortes, J. E.,
Baccarani, M.,
Agarwal, M. B.,
Undurraga, M. S.,
... Hochhaus, A.
(2012).Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION).Blood,119(5), 1123-1129.
Khoury, J. D.,
Solary, E.,
Abla, O.,
Akkari, Y.,
Alaggio, R.,
Apperley, J. F.,
... Hochhaus, A.
(2022).The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.Leukemia,36(7), 1703-1719.
Kockerols, C. C. B.,
Geelen, I.,
Levin, M. D.,
Janssen, J.,
Dinmohamed, A. G.,
Hoogendoorn, M.,
... Westerweel, P. E.
(2022).The use of hydroxyurea pretreatment in chronic myeloid leukemia in the current tyrosine kinase inhibitor era.Haematologica,107(8), 1940-1943.
Laneuville, P.
(2018).When to Stop Tyrosine Kinase Inhibitors for the Treatment of Chronic Myeloid Leukemia.Current treatment options in oncology,19(3), 15.
Mahon, F. X.,
Rea, D.,
Guilhot, J.,
Guilhot, F.,
Huguet, F.,
Nicolini, F.,
... Filmc
(2010).Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial.Lancet Oncology,11(11), 1029-1035.
Marin, D.,
Bazeos, A.,
Mahon, F. X.,
Eliasson, L.,
Milojkovic, D.,
Bua, M.,
... Khorashad, J. S.
(2010).Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib.Journal of Clinical Oncology,28(14), 2381-2388.
Richter, J.,
Lübking, A.,
Söderlund, S.,
Lotfi, K.,
Markevärn, B.,
Själander, A.,
... Koskenvesa, P.
(2021).Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR—final report from AFTER-SKI.Leukemia,35(8), 2416-2418.
Rousselot, P.,
Charbonnier, A.,
Cony-Makhoul, P.,
Agape, P.,
Nicolini, F. E.,
Varet, B.,
... Mahon, F. X.
(2014).Loss of major molecular response as a trigger for restarting tyrosine kinase inhibitor therapy in patients with chronic-phase chronic myelogenous leukemia who have stopped imatinib after durable undetectable disease.Journal of Clinical Oncology,32(5), 424-30.
Rousselot, P.,
Mollica, L.,
Guilhot, J.,
Guerci, A.,
Nicolini, F. E.,
Etienne, G.,
... Bouchet, S.
(2021).Dasatinib dose optimisation based on therapeutic drug monitoring reduces pleural effusion rates in chronic myeloid leukaemia patients.British Journal of Haematology,194(2), 393-402.
Sasaki, K.,
Jabbour, E. J.,
Ravandi, F.,
Short, N. J.,
Thomas, D. A.,
Garcia-Manero, G.,
... Kantarjian, H. M.
(2016).Hyper-CVAD plus ponatinib versus hyper-CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia: A propensity score analysis.Cancer,122(23), 3650-3656.
Saussele, S.,
Lauseker, M.,
Gratwohl, A.,
Beelen, D. W.,
Bunjes, D.,
Schwerdtfeger, R.,
... Hehlmann, R.
(2010).Allogeneic hematopoietic stem cell transplantation (allo SCT) for chronic myeloid leukemia in the imatinib era: evaluation of its impact within a subgroup of the randomized German CML Study IV.Blood,115(10), 1880-1885.
Saussele, S.,
Richter, J.,
Guilhot, J.,
Gruber, F. X.,
Hjorth-Hansen, H.,
Almeida, A.,
... Mahon, F. X.
(2018).Discontinuation of tyrosine kinase inhibitor therapy in chronic myeloid leukaemia (EURO-SKI): a prespecified interim analysis of a prospective, multicentre, non-randomised, trial.Lancet Oncology,19(6), 747-757.
Soverini, S.,
Hochhaus, A.,
Nicolini, F. E.,
Gruber, F.,
Lange, T.,
Saglio, G.,
... Martinelli, G.
(2011).BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: recommendations from an expert panel on behalf of European LeukemiaNet.Blood,118(5), 1208-1215.
Steegmann, J. L.,
Baccarani, M.,
Breccia, M.,
Casado, L. F.,
Garcia-Gutiérrez, V.,
Hochhaus, A.,
... Clark, R. E.
(2016).European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia.Leukemia,30(8), 1648-71.
Wisløff, F.,
Gedde-Dahl, T.,
Tjønnfjord, G. E.,
Holte, H.
(2014).Blodsykdommer(7 utg.)Oslo:Gyldendal.